Synaptic Vesicle Proteins

Synaptic Vesicle Proteins; SV

Synaptic vesicle protein is the important component of synaptic vesicle, that plays a role in the storage and transportation of neurotransmitters, vesicle fusion and release, as well as vesicle recycling/reusing. Synaptic vesicle protein includes synaptophysin, synaptotagmin, vesicle associated membrane protein (VAMP), synaptogyrin, vesicular neurotransmitter transporters, which could be divided into two classes: transport proteins involved in neurotransmitter uptake and trafficking proteins that participate in synaptic vesicle exo- and endocytosis and recycling. Synaptic vesicle protein cause the neurological diseases, such as Alzheimer's disease, epilepsy, depression^[1]^[2].

References:

[1]. Sankaranarayanan S, et al., Neuronal exocytosis[J]. Protein trafficking in neurons, 2007: 97-124.

[2]. Bonanomi D, et al., Protein sorting in the synaptic vesicle life cycle. Prog Neurobiol. 2006 Nov;80(4):177-217. [Content Brief]

Synaptic Vesicle Proteins Related Products (6):

By Effects:	Ligands (2) Modulators (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-119810

Seletracetam	Modulator	99.70%
Seletracetam (Ucb 44212), as an analog of the antiepileptic agent Levetiracetam, is a SV2A modulator for the research of epilepsy.

HY-136873

UCB-J	Ligand	99.62%
UCB-J is a ligand for synaptic vesicle protein 2A (SV2A) with pIC₅₀ values for human and rat SV2A of 8.15 and 7.6 respectively. UCB-J can be used to display and quantify the total synaptic density throughout the brain.

HY-157999

SDI-118	Modulator	98.86%
SDI-118 is an orally active modulator for synaptic vesicle glycoprotein 2A (SV2A) with an IC₅₀ of 13 nM.

HY-136873A

(Rac)-UCB-J	Ligand
(Rac)-UCB-J (Compound 23) is a ligand for synaptic vesicle protein 2A (SV2A), with a pIC₅₀ value of 8.2. (Rac)-UCB-J can be used as a PET tracer for SV2A to assist in the diagnosis of epilepsy research.

HY-180554

UCB1244283	Modulator
UCB1244283 is a synaptic vesicle glycoprotein 2A (SV2A) allosteric modulator. UCB1244283 binds to a secondary ligand-binding site in SV2A and enhances orthosteric ligand engagement when the orthosteric site is occupied, by stabilizing the occluded state and slowing ligand dissociation. UCB1244283 shows a clear protective effect against both tonic and clonic convulsions in sound-sensitive mice. UCB1244283 can be used for epilepsy research.

HY-119810B

Seletracetam lithium bromide	Modulator
Seletracetam (Ucb 44212) lithium bromide, an analog of the antiepileptic agent Levetiracetam, is a SV2A modulator for the research of epilepsy.

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