Synaptic Vesicle Proteins
Synaptic Vesicle Proteins; SV
Synaptic vesicle protein is the important component of synaptic vesicle, that plays a role in the storage and transportation of neurotransmitters, vesicle fusion and release, as well as vesicle recycling/reusing. Synaptic vesicle protein includes synaptophysin, synaptotagmin, vesicle associated membrane protein (VAMP), synaptogyrin, vesicular neurotransmitter transporters, which could be divided into two classes: transport proteins involved in neurotransmitter uptake and trafficking proteins that participate in synaptic vesicle exo- and endocytosis and recycling. Synaptic vesicle protein cause the neurological diseases, such as Alzheimer's disease, epilepsy, depression[1][2].
All Product Categories
-
Synaptic Vesicle Proteins Related Products (7)
Related Products (7)
-
Seletracetam
0 ImagesSynonyms: Ucb 44212Seletracetam (Ucb 44212), as an analog of the antiepileptic agent Levetiracetam, is a SV2A modulator for the research of epilepsy.
-
SDI-118
0 ImagesSDI-118 is an orally active modulator for synaptic vesicle glycoprotein 2A (SV2A) with an IC50 of 13 nM.
-
UCB-J
0 ImagesUCB-J is a ligand for synaptic vesicle protein 2A (SV2A) with pIC50 values for human and rat SV2A of 8.15 and 7.6 respectively. UCB-J can be used to display and quantify the total synaptic density throughout the brain.
-
UCB1244283
0 ImagesCat. No.: HY-180554CAS No.: 300587-89-7UCB1244283 is a synaptic vesicle glycoprotein 2A (SV2A) allosteric modulator. UCB1244283 binds to a secondary ligand-binding site in SV2A and enhances orthosteric ligand engagement when the orthosteric site is occupied, by stabilizing the occluded state and slowing ligand dissociation. UCB1244283 shows a clear protective effect against both tonic and clonic convulsions in sound-sensitive mice. UCB1244283 can be used for epilepsy research.
-
(Rac)-UCB-J
0 ImagesCat. No.: HY-136873ACAS No.: 1604786-87-9(Rac)-UCB-J (Compound 23) is a ligand for synaptic vesicle protein 2A (SV2A), with a pIC50 value of 8.2. (Rac)-UCB-J can be used as a PET tracer for SV2A to assist in the diagnosis of epilepsy research.
-
MR-39
0 ImagesCat. No.: HY-184654CAS No.: 2169267-60-9MR-39 is a FPR2 agonist (EC50 = 3.9 μM). MR-39 activates FPR2 to promote neuroinflammation resolution (downregulates IL-1β and TNF-α, modulates NF-κB), upregulates synaptic proteins (synaptic proteins) and improves dendritic spine morphology. MR-39 inhibits MAPK/ERK and AKT phosphorylation in glioblastoma, induces S-phase arrest, and suppresses migration, angiogenesis, and hypoxic adaptation. MR-39 reduces Aβ plaque burden via inhibiting MyD88/NF-κB and NLRP3 inflammasome. MR-39 can be used for research on autism spectrum disorder, Alzheimer's disease, and glioblastoma.
-
Seletracetam lithium bromide
0 ImagesCat. No.: HY-119810BCAS No.: 2024584-38-9Synonyms: Ucb 44212 lithium bromideSeletracetam (Ucb 44212) lithium bromide, an analog of the antiepileptic agent Levetiracetam, is a SV2A modulator for the research of epilepsy.
